Is wind going to factor much into the equation? If wind will be a major factor I like the 243. Heavier wind buckers, yes, a little more powder, but, one shot kills when windy is less powder than 2 or three rounds with 223. Now don't get me wrong, nothing against the 223, I shoot a Ruger bolt 77 target/varmit, but I really like the wind bucking qualities of the 243 when yardage gets long.