The rifle I reach for the most this year is my new 338-06 Improved. It was built by John Gallagher in Jasper. I also like to use cartridges that are outside the norm. The list of rifles I've used is:
257 Roberts 7X57 7mm Rem Mag 308 Winchester 30-06 300 H & H Magnum 300 Winchester Magnum 300 Weatherby Magnum 338 Winchester Magnum 35 Whelen Improved 375 H & H Magnum
Bought a 264 Winchester Magnum this year but haven't used it yet.