How long are you going for? When we went we stayed in the park which significantly cut down on the driving. It may not seem like a long distance to different parts of the park, but there will inevitably be a bunch of peckerheads holding up traffic to stop and look at the 3000th bison of the day. We stayed a few days in the canyon area, a few in the lake area, and a night at old faithful. I highly recommend spending some time in the Tetons while you're there as well if you have time.

Get the guidealong app ahead of time (previously called gypsy app)